Cyclobenzaprine Flexeril Side Effects & Interactions

FLEXERIL may enhance the effects of alcohol, barbiturates, and other CNS depressants. Less frequent dosing should be considered for hepatically impaired or elderly patients (see PRECAUTIONS, Impaired Hepatic Function, and Use in the Elderly). Tell your doctor if you are pregnant or plan to become pregnant during treatment with Flexeril. It is unknown if Flexeril passes into breast milk or if it could harm a nursing baby.

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The kidneys of older adults may not work as well as they used to. As a result, more of a drug stays in your body for longer. Your doctor may start you on a lowered dose or a different dosing schedule. This can help keep levels of this drug from building up too much in your body. To help avoid interactions, your doctor should manage all of your medications carefully. Be sure to tell your doctor about all medications, vitamins, or herbs you’re taking.

What if I miss a dose?

Cyclobenzaprine is used short-term to treat muscle spasms. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter half life of flexeril medicines and natural products. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment.

Usually, people won’t die from a cyclobenzaprine overdose. There are over 12,000 people in the U.S who will go to the emergency room looking to be treated for Flexeril overdose. A study showed that 209 people who overdosed on Flexeril on its own survived the ordeal. Mixing the drug with other substances, however, has shown to cause accidents leading to death. You might start to feel some of the effects of cyclobenzaprine within 20 to 30 minutes of taking it. The peak concentration varies, depending on what formulation you take.

CYCLOBENZAPRINE (sye kloe BEN za preen) treats muscle spasms. It works by relaxing your muscles, which reduces muscle stiffness. It belongs to a group of medications called muscle relaxants. Achieving better sleep is directly related to your overall mental and physical health. If you’re facing acute pain or recovering from a recent injury, chances are, your sleep quality has been compromised. While medications like cyclobenzaprine can help, adopting healthy sleep habits and making minor changes to your daily routine can ease both pain and insomnia symptoms.

• Avoid driving or hazardous activity until you know how this medicine will affect you.
• Avoid taking MAO inhibitors (isocarboxazid, linezolid, metaxalone, methylene blue, moclobemide, phenelzine, procarbazine, rasagiline, safinamide, selegiline, tranylcypromine) during treatment with this medication.
• Do not use it later for another condition unless your doctor directs you to do so.
• During pregnancy, this medication should be used only when clearly needed.

The plasma concentration of cyclobenzaprine is increased in patients with hepatic impairment (see CLINICAL PHARMACOLOGY, Pharmacokinetics, Hepatic Impairment). Take this medication by mouth with or without food as directed by your doctor. Do not increase your dose or use this drug more often or for longer than prescribed. Your condition will not improve any faster, and your risk of side effects will increase. It’s not considered a dangerous method of getting rid of specific muscular pain. It is given to patients who are more likely to abuse opiate pain killers and is considered less risky for abuse and addiction.

Are methocarbamol and cyclobenzaprine the same?

Where L is the concentration of radioligand in each replicate, having affinity KD (Cheng and Prusoff, 1973). Each experimental condition was run in triplicate, and each experiment was performed a minimum of three times to determine S.D. Saturation binding experiments were conducted as we have reported previously (Moniri et al., 2004). Briefly, cells were transfected with 2 μg of H1R and prepared as described above, except membranes were prepared in buffer containing 25 mM Tris-HCl, 4mM MgCl2 (pH 7.5) and the filters were washed with identical buffer containing 0.1% BSA.

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It’s not advised to drink alcohol at all while they’re being treated with Flexeril. People that combine Flexeril and alcohol also may not think properly and are more susceptible to making bad choices. Operating a vehicle while intoxicated, walking through a bad part of town, and other risks to physical harm may end up being more likely when abusing Flexeril and alcohol. There have been a number of fatalities reported as a result of the Flexeril and alcohol combination that occurred from physical harm caused by over-intoxication. Cyclobenzaprine can increase the effects of CNS depressants, such as alcohol, opioids, allergy medications, and sleeping pills. If a person is prescribed cyclobenzaprine, they should make sure their health care provider knows all medications they are taking (including over-the-counter medications), as well as if they drink alcohol or use other drugs.

Physical activity can not only improve sleep but also keep your muscles strong and flexible. If you’re currently recovering from an injury and undergoing physical therapy, check with your therapist before adopting a new exercise routine. A daily walk or other low-impact exercises can work wonders for your physical and mental health. Most patients taking the short-acting cyclobenzaprine tablets report feeling the effects within 20 to 30 minutes and lasting for four to six hours. The long-lasting capsules take slightly longer to take effect but you may feel relief for up to 24 hours.

Data sources include IBM Watson Micromedex (updated 3 Sep 2023), Cerner Multum™ (updated 28 Aug 2023), ASHP (updated 10 Aug 2023) and others. Other drugs may interact with cyclobenzaprine, including prescription and over-the-counter medicines, vitamins, and herbal products. There is also the possibility of becoming psychologically dependent on Flexeril because of the feelings of relaxation. Flexeril on its own may not be as susceptible to creating addiction but when it’s abused, there’s a much greater risk. And when cyclobenzaprine and alcohol, opioids, or drugs are used in combination, that risk becomes even higher.